摘要
目的 探讨凋亡蛋白Bcl 2家族中Bax及Bcl 2两个亚族各在慢性肝炎、肝硬化及肝癌发生、发展中对凋亡的调节作用。方法 15 6例慢性肝病患者中 ,慢性肝炎 72例 ,肝硬化 2 9例 ,肝癌 5 5例 ,采用免疫组化染色检测以上两亚族凋亡蛋白在其肝组织中的表达。结果 慢性肝炎组Fas及Fas配体 (FasL)阳性表达率 (87 5 % ,94 4% )明显高于肝癌组 (5 4 5 % ,5 2 7% ) ,P <0 0 1,Fas(+ )、(+ + )及FasL(+ + )表达量也明显高于肝癌组 ;慢性肝病患者肝组织Bax亚族表达均明显高于Bcl 2亚族。结论 慢性肝病状态下 ,凋亡蛋白Bcl 2家族参与了肝组织细胞凋亡的调节。
Objective To analyse the expression of Fas and Fas ligand(FasL) in patients of chronic hepatitis,liver cirrhosis and hepatocelluar carcinoma and to study the regulation of apoptosis by Bax and Bcl-2 subfamilies.Methods The subfamily of Bcl-2 in the liver tissue was studied by immunohistochemistry.Results In 156 cases of chronic liver disease the expression levels of Fas and FasL in the chronic hepatitis group were significantly higher than that in hepatocellular carcinoma group(P<0.01).The expression level of Bax subfamily in the chronic hepatitis group was significantly higher than that of Bcl-2 subfamily.Conclusion It is suggested that Bcl-2 family is involved in the regulation of apoptosis in the chronic liver diseases.
出处
《中华内科杂志》
CAS
CSCD
北大核心
2000年第12期808-810,I026,共4页
Chinese Journal of Internal Medicine
基金
国家自然科学基金!资助项目 (39770 6 6 0 )
北京军区重点课题!资助项目 (95B0 0 8)
