泌尿生殖道支原体感染273例耐药研究

Resistance Study of Mycoplasma to Antibiotics in 273 Genitourinary Infections

目的 为了解本地区支原体对抗生素的耐药情况及诱导因素,指导临床合理用药,有效控制性病流行。方法 对泌尿生殖道感染支原体培养阳性的样本进行抗生素药敏测定,并设对照组观察。结果 273例阳性样本中,212例对10种抗生素有不同程度耐药,耐药样本占77.66％,其中对红霉素、罗红霉素、四环素、强力霉素、美满霉素耐药率较高,对阿奇霉素与氧氟沙星耐药率较低,曾用抗生素治疗过的病人耐药率显著高于初诊患者。结论 本地区支原体耐药情况相当严重,主要由不正规治疗及滥用抗生素引起,建议性病诊疗单位常规开设支原体药敏实验,根据药敏结果合理选药。

Objective To explore the resistance of myeoplasma to antibiotics in Pingdingshan region in Henan province and, clarify the inducing factors for myeoplasma to the resistance of antibiotics to guide STD drug practice at clinics correctly and, control the epidemic of STD effectively in Pingdingshan. Methods The sensitive test of STD drugs to myeoplasma cultured with the specimen from the Genitourinary infections was performed and, the control group was set up. Results Of 273 myeoplasma positives 212 ones, accounting for 77.66% of the total, were found to be resistance of varying degrees to 10 kinds of antibiotics. The resistances of myeoplasma to erythomycin, roxithromycin, tetrcyclin, doxcyclin and mynocyclin were stronger than those to azithromycin and ofloxacin. The STD patients who had been treated previously by antibiotics were conferred the stronger resistance to antibiotics than those who first visited to STD clinics. Conclusion The resistance of myeoplasma to antibiotics is very serious in Pingdingshan region, which is induced by incorrect treatment and abuse of antibiotics. It is suggested that STD drug sensitive test be developed routinely and, STD drugs be rationally selected in accordance with STD drug sensitive test while treating STD patients in Pingdingshan region.