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不同种类的百日咳菌液致大鼠感染性脑水肿模型的比较 被引量:1

Comparison of infectious brain edema models induced by different kinds of pertussis bacilli in rats
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摘要 目的 :了解不同种类的百日咳菌液致大鼠感染性脑水肿 (感脑 )模型的差异 ,以寻找一种新的感脑模型。方法 :SD大鼠随机分为生理盐水对照组 (NS) ,粗制百日咳菌液组 (PBR)和精制百日咳菌液组 (PBP)。分别使用粗制百日咳菌液和精制百日咳菌液制作感脑模型后 ,检测脑组织含水量、伊文思蓝 (EB)含量和钠钾离子含量。结果 :PBR组和PBP组大鼠脑含水量、钠离子含量和EB含量较NS组明显增高 ,钾离子含量明显降低 (P <0 .0 1)。PBR组全部大鼠左半球脑组织明显蓝染 ;而PBP组仅 6只大鼠脑组织出现蓝染。PBR组大鼠脑组织EB含量明显高于PBP组 (P <0 .0 1)。结论 :粗制百日咳菌液和精制百日咳菌液均可致大鼠感脑模型 ,前者以混合性脑水肿为主 。 Objective: To understand the difference of infectious brain edema models induced by varied kinds of pertussis bacilli in rats and to look for a new infectious brain edema model. Methods: Sprague Dawley rats were randomly divided into 3 groups: normal saline group(NS); rude pertussis bacilli(PBR); purified pertussis bacilli(PBP). After infectious brain edema model was induced by rude pertussis bacilli or purified pertussis bacilli, the water content(WC), Evans blue content(EB), Na + and K + content in brain tissues were measured. Results: The WC, EB and Na + contents in brain tissues in PBR and PBP groups were significantly increased than those in NS group; K + content was significantly decreased in PBR and PBP groups than that in NS group(P<0.01). Evan's blue discoloration was demonstrated in all rats of PBR group, but 6 rats of PBP group showed bluish discoloration. EB content in brain tissues was significantly increased in PBR group than that in PBP group. Conclusions: The infectious brain edema model can be induced by rude pertussis bacilli or purified pertussis bacilli in rats, the former gives priority to mixed brain edema, and the latter mainly avails cytotoxin brain edema. [
出处 《湖南医科大学学报》 CSCD 2000年第6期573-575,共3页 Bulletin of Hunan Medical University
关键词 感染性脑水肿 百日咳菌液 疾病模型 大鼠 brain edema pertussis bacilli * disease model,animal rats [Bull Hunan Med Univ, 2000,25(6):0573 l
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  • 1文飞球,中国现代医学杂志,1994年,4卷,4期,22页
  • 2杨于嘉,颅内压与颅内压增高,1993年
  • 3团体著者,实用儿科杂志,1991年,6卷,295页
  • 4徐正谷,湖南医学院学报,1987年,12卷,1期,47页
  • 5团体著者,湖南医学院学报,1983年,8卷,4期,353页

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