低剂量诺维本持续静脉输注与常规用法治疗晚期非小细胞肺癌的比较

Comparative Study of Continuous Navelbine Infusion and Conventional Use for Advanced Non－Small Cell Lung Cancer

目的：比较诺维本持续静脉输注与常规用法治疗晚期非小细胞肺癌的疗效和毒性。方法：统计分析持续静脉输注和常规用法组治疗的49例晚期非小细胞肺癌病例的临床资料。结果：持续输注组有效率为48％，常规用法组有效率为41．7％，前者略高于后者，两者比较无显著差异（P ＞0．05，但达到有效所用的时间前者平均56天，后者为89天，两者比较有显著差异（P＜ 0．05。毒副反应主要为骨髓抑制和局部静脉炎。结论：持续静脉输注诺维本是治疗晚期非小细胞肺癌较为有效而安全的新方法。

Objective To compare the efficacy and toxicity of continuous Navelbine infusion and conventional use for advanced non－small cell lung cancer NSCLC． Methods The clinical data of 49 cases of advanced NSCLC treated with continuous Navelbine infusion and conventional use were analysed． Results The response rate was 48％ in patients treated with continuous infusion and 41．7％ in those treated with conventional use． It showed that the former was slightly higher than the latter without significant difference P ＞0．05． The average time to reach the curative effect were 56 days in the former 89 days in the latter with significant difference P＜ 0．05． The major toxic reactions were myelosuppression and local venous inflammation． Conclusion Continuous Navelbine infusion is an effective safe method for advanced NSCLC patients．