首发Tourette综合征静息态功能磁共振脑比率低频振幅的研究

Study of fractional amplitude of low frequency fluctuation (fALFF) of resting-state functional magnetic resonance imaging (fMRI) in patients with first-episode Tourette syndrome

目的 探讨首发Tourette综合征（TS）静息态下功能磁共振（fMRI）脑比率低频振幅（fALFF）的特征.方法 16例TS患儿（研究组）和16例良好匹配的健康受试者（对照组）均接受静息态功能共振（fMRI）扫描.在0.01～0.1 Hz频段内计算fALFF值,两组进行独立样本t检验.结果 研究组患儿基于BOLD信号的fALFF值在如下脑区强于对照组：左侧梭状回（t =4.36,P＜0.05）、右侧壳核（t=3.81,P＜0.05）；研究组患儿基于BOLD信号的fALFF值在如下脑区弱于对照组：左侧额下回三角部（t=-6.13,P＜0.05）、右侧额中回（t=-4.35,P＜0.05）、左侧额上回（t=-4.51,P＜0.05）、左侧枕中回（t=-6.13,P＜0.05）、左侧罗兰迪克岛盖（t=-4.58,P＜0.05）、右侧罗兰迪克岛盖（t=-4.28,P＜0.05）.结论 首发Tourette综合征患儿在一些脑区存在脑功能活动的异常,有助于揭示Tourette综合征的神经生理机制.

Objective To explore the characteristics of fractional amplitude of low frequency fluctuation （fALFF） of resting-state functional magnetic resonance imaging （fMRI） in patients with first-episode Tourette syndrome. Methods 16 subjects with first-episode Tourette syndrome and 16 well-matched healthy controls were scaned with resting-state fMRI. Values of fALFF were calculated in the tape limit ranging from 0.01 Hz to O. 1 Hz. Independent-samples T Test was performed between the two groups. Results TS patients showed sig, nificantly higher fALFF than healthy controls in left fusiform gyrus （ t = 4. 36, P 〈 0.05 ）, right putamen （ t --- 3.81, P 〈 0.05 ）. In addition, fALFF in TS patients were significantly lower than those in healthy controls in left pars triangularis gyri frontalis inferioris （t = -6. 13, P 〈0.05）, right midfrontal gyrus （t = -4. 35, P 〈0.05）, left superior frontal gyros （t = -4. 51, P 〈0.05）, left midoccipital gyrus （ t = - 6. 13, P 〈 O. 05 ）, left rolandic operculum （ t = - 4. 58, P 〈 0.05 ） and right rolandic operculum （ t = -4. 28, P 〈 0.05 ）. Conclusion There are abnormal functional activities in some brain areas in patients with TS. Further neuroimaging study may contribute to understand the underlying neurophysiological mechanism of TS.