氟伏沙明与氯米帕明治疗青少年强迫症的对照研究

A control study of fluvoxamine and clomipramine in the treatment of adolescents with OCD

目的比较氟伏沙明与氯米帕明治疗青少年期强迫症的疗效和不良反应。方法共纳入强迫症患者42例,随机分为氟伏沙明组和氯米帕明组,疗程8周。应用耶鲁-布朗强迫症量表(Y-BOCS)、汉密尔顿焦虑量表(HAMA)评定疗效,治疗中需处理的不良反应症状量表(TESS)评价不良反应。结果氟伏沙明组治疗总有效率86.4%,氯米帕明组治疗总有效率86.4%,两组比较差异无统计学意义(P>0.05)。两组治疗后第4、8周末YBOCS评分、HAMA评分与治疗前比较差异有显著统计学意义(P<0.01)。氟伏沙明组与氯米帕明组不良反应发生率差异有统计学意义(P<0.05)。结论氟伏沙明对于青少年期强迫症状的治疗是安全有效的。

Objective To study the efficacy and adverse reactions of fluvoxamine and clomipramine in the treatment of adolescents with OCD. Methods 42 adolescents with OCD were randomized into fluvoxarnine group （21 cases） and clomipramine group （21 cases） treated with fluvoxamine and clomipramine respectively for 8 weeks. All patients were assessed with Yale-Brown Obsessive Compulsive Scale （Y-BOCS） and Hamilton Anxiety Scale （HAMA） to evaluate the efficiency and were assessed with Treatment Emergent Symptom Scale （TESS） to evaluate the side effects. Results There was no significant difference in response rate between fluvoxamine group and clomipramine group （ 86.4% vs. 86.4%, P = 1.00）. Compared with the baseline, scores of Y-BOCS and HAMA in both groups decreased significantly at the 4th, 8th week of the treatment （P 〈0.01）. The rate of adverse reactions in fluvoxamine group was significantly lower than that in clomipramine group （35% vs. 70%, P 〈 0.05）. Conclusion Fluvoxamine is safe and effective in the treatment of adolescents with OCD.