舍曲林对女性尿道综合征患者P300及生存质量的影响

Influence of sertraline on P300 and quality of life in female patients with urethral syndrome

目的研究女性尿道综合征(FUS)患者P300特点,探讨对照舍曲林治疗对FUS患者P300及生存质量的影响。方法对84例FUS患者(FUS组)及76名健康对照组(对照组)于入组前接受卡特尔16种人格因素问卷(16PF)、P300测查、蒙特利尔认知评估量表(MoCA)、《世界卫生组织生存质量测定量表简表》(WHOQOLBREF)、汉密尔顿焦虑量表(HAMA)及汉密尔顿抑郁量表(HAMD)检测;FUS组经过12周舍曲林治疗,再次进行MoCA量表、WHOQOL-BREF评估、P300测查,尿道综合征症状评分量表(FUSS)检测。结果 FUS组16PF因子分中,乐群性、聪慧性、稳定性、实验性、自律性因子得分均低于对照组(P<0.01);敏感性、怀疑性、忧虑性、紧张性因子得分高于对照组(P<0.01);治疗前,FUS组MoCA评分、P300波幅、WHOQOL-BREF测试在生理领域、心理领域、社会关系领域的评分均低于对照组(P<0.01),HAMA评分和P300潜伏期高于对照组(P<0.01);治疗后FUS组P300波幅、WHOQOL-BREF测试生理领域、心理领域、社会关系领域的评分较治疗前明显增加(P<0.01),HAMA量表评分及FUSS量表评分较治疗前明显减少(P<0.01),FUS组P300波幅及心理领域评分仍低于对照组(P<0.01)。结论尿道综合征患者存在明显人格异常及认知功能障碍,舍曲林治疗能改善患者认知功能和生存质量,P300可作为评价认知功能的敏感指标。

Objective To study the characteristics of personality and P300, and to explore the influence of sertraline on P300 and quality of life in patients with female urethral syndrome （FUS）. Methods 84 patients with FUS and 76 healthy controls were assessed with Cattell 16 Personality Factor Questionnaire （16-PF）, P300, Montreal Cognitive Assessment Scale （MoCA）, WHO Quality of Life Scale （WHOQOL-BREF）, Hamilton Anxiety Scale （HAMA）, Hamilton Depression Rating Scale（HAMD） at baseline. After 12-week treatment of sertraline, patients with FUS were reassessed with MoCA,WHOQOL-BRFF,P300 and Female Urethral Syndrome Scale（FUSS）. Results Factor scores of warmth, reasoning, emotional stability, opening to change, perfectionism in 16-PF in FUS group were significantly lower than those in control group （P 〈 0. O1 ）. While factor scores of sensitivity, vigilance, apprehension, tension in FUS group were significantly higher than those in control group （ P 〈 0.01 ）. At the baseline, scores of MoCA, amplitude of P300, factor scores of physical domain, psychological domain and social relations domain in WHOQOL-BREF in FUS group were significantly lower than those in control group （P 〈 0.01 ）, score of HAMA and latency of P300 in FUS group were significantly higher than those in control group （ P 〈 0.01 ）. Compared with baseline, amplitude of P300 and factor scores of three domains mentioned above in WHOQOL-BREF in FUS group increased significantly , and scores of HAMA and FUSS decreased significantly at the end of the treatment （ P 〈 O. 01 ）. However, amplitude of P300 and factor score of psychological domain in WHOQOL-BREF in FUS group at the end of the treatment were significantly lower than those in control group （P 〈 0. 01 ）. Conclusion There are serious personality abnormalities and cognitive dysfunctions in patients with FUS. Sertraline can improve cognitive function and quality of life of patients with FUS. P300 can be used as a sensitive index for the evaluation of cognitive function.