老年焦虑抑郁障碍共病54例临床研究

Clinical analysis of 54 elderly patients with comorbidity of anxiety and depressive disorder

目的探讨老年焦虑抑郁障碍的临床特征、诊断及治疗方法。方法选取54例符合入组标准及排除标准的患者进行临床研究,归纳临床症状并进行统计分析。用汉密尔顿焦虑量表(HAMA)和汉密尔顿抑郁量表(HAMD)进行评分,对比治疗前后的评分变化,并以HAMA和HAMD减分率判定疗效。结果老年焦虑障碍多与抑郁共病,躯体主诉多为其主要特点。治疗后第2周末开始起效,疗效随时间延长同步上升,治疗后第2、4、8周末HAMA、HAMD量表评分与治疗前比较,有显著性差异(P<0.05,P<0.01)。药物及心理治疗的总有效率90.75%。结论老年焦虑障碍多与抑郁共病,及时干预治疗效果满意。

Objective To explore the clinical characteristics, diagnosis and treatment in elderly patients with eomorbidity of anxiety and depressive disorder. Methods A total of 54 elderly patients with comorbidity of anxiety and depressive disorder were enrolled in this study. Clinical informations were summed up and analyzed. All patients were assessed with Hamilton Depression Scale （HAMD） and Hamilton Anxiety Scale （HAMA） at baseline and at the end of the treatment. The efficacy was evaluated by using the reduction rate of HAMD and HAMA. Results Anxiety disorder was often comorbided with depression in elderly patients and was characterized by many somatic complaints. They responsed to treatment at the end of the 2nd week and the efficacy increased with the time prolonged. Compaired the scores of HAMA and HAMD significantly at the 2nd ,4th, 8th after treatment than before treatment （P 〈 0.05 or P 〈 0.01 ）. The effective rate of drug therapy comorbided with psychotherapy was 90.75%. Conclusion Comorbidity of anxiety and depression is common in elderly patients. Satisfactory efficacy can be obtained by using early prevention.