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黏附因子CD44的活化状态及其在肿瘤靶向治疗中的研究进展 被引量：2

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摘要 CD44（clusterofdifferentiation44）指白细胞分化抗原簇第44号，是一类重要的黏附分子，广泛分布于细胞表面，如淋巴细胞、单核细胞、成纤维细胞、内皮细胞等口]。不同细胞表面CD44与透明质酸（HA）结合活性不同，活化状态存在很大差异。许多正常细胞表面CD44处于相对静止状态，而许多肿瘤细胞表面CD44处于高度活化状态，能与其主要配体HA结合，参与肿瘤的发生、发展及转移等。
作者 侯利丹 高锋
机构地区 上海交通大学附属第六人民医院中心实验室
出处 《重庆医学》 CAS CSCD 北大核心 2013年第27期3313-3315,共3页 Chongqing medicine
基金 国家自然科学基金资助项目(81071814 81172027 81272479)
关键词 肿瘤 CD44 透明质酸
分类号 R730.5 [医药卫生—肿瘤]
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参考文献32

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同被引文献40

  • 1王文祥,肖高明,文继舫.CD44、基质金属蛋白酶及其抑制剂与肿瘤浸润和转移[J].中国现代医学杂志,2005,15(5):712-715. 被引量：11
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重庆医学
2013年 第27期

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