摘要
目的 :研究穿心莲注射液对麻醉大鼠的降压作用及其机制。方法 :穿心莲注射液 4mg/kg舌下静脉注射 ,测量其颈动脉血压变化 ,并于 30分钟时测定血浆一氧化氮 (NO)及内皮素 (ET)的含量。结果 :注射穿心莲注射液后血压迅速下降 ,30分钟降至最低 ,且具有快速耐受性。 30分钟时血浆NO含量升高 ,ET水平下降。结论 :穿心莲注射液对麻醉大鼠有降压作用 。
Objective To study the effect and mechanism of injection of andrographis paniculata nees (APN) on blood pressure in anesthetized rats.Methods The rats were anesthetized by intra abdominal injection of 20% urethan(5ml/kg),then injected with ANP through sublingual vein.Obserre blood pressure of cervical artery and determine nitric oxide(NO) and endothelin (ET)of plasma in 30min.Results Blood pressure was falling quickly after injecting APN,and rapidly showed a drugfast phenomenon.Blood pressure was falling to the lowest point in 30 min.Conclusion ANP can drop blood pressure and the mechanism may be associated with increasing NO content and decreasing ET concentration in plasma.
出处
《咸宁医学院学报》
2000年第4期244-245,共2页
Journal of Xianning Medical College
关键词
穿心莲注射液
降压作用
内皮素
麻醉大鼠
NO
Andrographis Paniculata Nees
Depressurized effect
Nitro Oxide
Endothelin
