乌梅对未孕和早孕大鼠子宫平滑肌电活动的影响及其机理探讨

Study on Effects of Fructus Mume on Myoelectric Activity of Uterine Smooth Muscle of Unpregnancy and Early pregnancy Rats and Its Action Mechanism

目的 :观察乌梅水煎液对未孕和早孕大鼠子宫平滑肌电活动的影响及研究其作用机理。方法 :在大鼠一侧子宫角上埋植一对双极电极 ;腹腔注射乌梅水煎液后观察对大鼠子宫肌电的影响。结果 :较大剂量的乌梅水煎液可使正常大鼠子宫平滑肌慢波的平均振幅增大 ,暴发式排放的丛状肌电波的发生率增多 ,最大振幅增大 ;而早孕大鼠对乌梅更加敏感。结论 :乌梅可明显增强未孕和早孕大鼠的子宫肌电活动 ,可能是通过增强了平滑肌起步细胞的电活动并使其动作电位去极化的速度加快所致。由此阐明其抗着床、抗早孕的临床作用机理。

Objective:To investigate the effect of decoction of Fructus Mume (DFM) on the myoelectric activity of uterine smooth muscle of unpregnancy and early pregnancy rats and study its action mechanism.Methods: A pair of bipolar electrode was implanted on the serous surface of rat uterus. The DFM was injected into abdominal and the changes of uterine myoelectrical activity were observed.Results: The higher dose of DFM could enlarge the average amplitude of slow wave of uterine smooth muscle myoelectricity as well as increase the incidence and the maximal amplitude of the outbreak plexiform myoelectric wave. On the other hand, rats during early pregnancy were more sensitive to the DFM. Conclusions: The DFM enhances the myoelectricity activity of uterine smooth muscle of unpregnancy and early pregnancy rats which may result from enhacing the start cells electric activity and speeding up the action potential depolarization. Thus the DFM can serve as an effective clinical drug for anti early pregnancy.