医用臭氧在治疗腰椎间盘突出症中相关阼用的研究进展

The Research Progress of Ozone＇s Action in Treating Protrusion of Lumber Intervertebral Disc

医用臭氧是治疗腰椎间盘突出症常用的微创方法，已取得了良好的临床疗效，注射部位包括盘内、椎旁以及椎间孔内外等。目前的研究表明，臭氧对正常的椎间盘组织和细胞可产生氧化作用。在治疗腰椎间盘突出症中的作用主要包括对髓核的直接氧化作用、调节氧化应激、调节免疫反应、激活镇痛系统和增加氧供使炎症介质减少等。其中，有些作用机制的具体作用途径尚未完全阐明，而大量的临床证据以及明确臭氧的作用途径为其临床应用的推广起到了至关量要的作用。

Ozone therapy is a common minimally invasive therapeutic method in treating protrusion of lumber intervertebral disc which has acquired favorable therapeutic effects, and it includes intradiscal, paravertebral and intraforaminal injection. It has been shown that ozone has oxidative effect on normal intervertebral disc and cells. The mechanisms of ozone therapy involve direct oxidative action to nucleus pulposus, modulating oxidative stress, regulation of immune system, activating the descending antinociceptive system and increasing oxygen supplies which decrease the production of inflammatory mediators. However, some of these mechanisms have not been well understood. So a quantity of clinical evidence and the well know of the mechanisms of ozone will be of vital importance to the better clinical application of ozone.