基于STA-Compact检测系统的儿童和青少年APTT和PT参考区间调查

Investigation on APTT and PT reference intervals in children and adolescents for STA-Compact hemostasis system

目的通过回顾性分析研究儿童活化部分凝血活酶时间(APTT)和凝血酶原时间(PT)参考区间。方法收集STA-Compact检测系统检测的术前凝血功能检查资料,通过对住院病史的查阅,将有出血史和血液疾病史及有心肺和肝肾疾病史的患儿资料排除在外,以接受择期非感染手术的1 d～18岁儿童为主要研究对象,检查前2周未服用抗凝及抗血小板药物,共4 166例儿童样本符合要求,纳入分析。将所有儿童按年龄分为≤30 d组、31 d～1岁组、2～6岁组、7～14岁组和15～18岁组。应用SPSS17.0软件对儿童APTT和PT参考区间进行统计分析。结果各组APTT和PT值均无性别差异。≤30 d组与31 d～1岁组、2～6岁组与7～14岁组APTT结果以及2～6岁组与7～14岁组PT结果差异无统计学意义(P>0.05),其余各组间结果差异均有统计学意义(P=0.000)。结论通过回顾性资料分析,建立了基于STA-Compact检测系统的新生儿和儿童的APTT和PT参考区间。

Objective To investigate activated partial thromboplastin time （APIT） and prothrombin time （PT） reference intervals in children and adolescents by retrospective analysis. Methods Patients in Shanghai Children＇s Medical Center for surgical procedures and aged from 1 day old to 18 years old were enrolled for this study after excluding patients with hematological disorders, patients with cardiopulmonary diseases and patients with diseases of liver and kidney. A coagulation screening test was performed for all patients who were not treated with anti-coagulation or anti-platelet drugs for the past 2 weeks with a STA-Compact hemostasis system. There were 4 166 children eligible for this study, and all the children were classified into ≤30 d, 31 d-1 year, 2-6 years, 7-14 years and 15-18 years groups, respectively. The SPSS 17.0 software was used to analyze APIT and PT data. Results The sex distribution had no difference among the 5 groups. No statistical significance was observed on APTT results between the group of ≤30 d with the groups of 31 d-1 year, 2-6 years and 7-14 years, and on PT results among the group of 2-6 years with the group of 7-14 years （P 〉0.05）. There were statistical significance among the other groups （P = 0.000）. Conclusions Through retrospective analysis, the reference intervals of APIT and PT for STA-Compact hemostasis system in children and adolescents are established.