2型糖尿病患者铁蛋白浓度与胰岛素抵抗的相关性研究

Study on the correlationship of ferritin concentration with insulin resistance in patients with type 2 diabetes mellitus

目的探讨不同年龄汉族人群中血清铁蛋白(SF)和2型糖尿病(T2DM)的关系。方法分别对100例T2DM患者(T2DM组)、100例高铁蛋白非T2DM患者(高SF组)及100名健康体检人群(正常对照组)进行空腹血糖(FBG)、空腹胰岛素(FINS)、SF和糖化血红蛋白(HbA1c)及血细胞参数[血红蛋白(Hb)、血细胞压积(Hct)、红细胞平均体积(MCV)和红细胞平均血红蛋白量(MCH)]检测,并对结果进行相关分析。结果 T2DM组SF、FBG、HbA1c、FINS、稳态模型评估胰岛素抵抗(HOMR-IR)水平明显高于正常对照组(P<0.05),SF与FBG、HbA1c、FINS、HOMR-IR呈明显正相关(r值分别为0.140、0.171、0.189、0.316,P值分别为0.003、0.023、0.004、0.001)。T2DM组Hb、FBG、HbA1C、FINS、HOMA-IR明显高于高SF组(P<0.05),高SF组SF、MCV明显高于正常对照组(P<0.05)。结论 T2DM患者可能存在铁超负荷,导致SF水平升高,且与胰岛素抵抗有一定的相关性。

Objective To investigate the relationship of serum ferritin （SF） with type 2 diabetes mellitus （T2DM） in Chinese Han population with different ages. Methods A total of 100 patients with T2DM （ T2DM group ）, 100 patients with high ferritin and non-T2DM （ high SF group ） and 100 healthy subject controls （ control group ） were enrolled for the determinations of fasting blood glucose （FBG） , fasting insulin （FINS）, SF and glycosylated hemoglobin （ HbAlc ） and blood parameters [ hemoglobin （Hb） ,hematocrit （Her） ,mean corpuscular volume （MCV） and mean cell hemoglobin （MCH） ]. The correlationship was analyzed. Results The SF, FBG, HbAlc, FINS and homeostasis model assessment of insulin resistance （HOMR-IR） in T2DM group were significantly higher than those in control group （P 〈 0.05）. SF had a significant correlation with FBG , HbAlc ,FINS and HOMR-IR （r = 0. 140, 0. 171,0. 189 and 0.316, P =0.003,0.023,0. 004 and 0.001 ）. The Hb, FBG, HbA1c, FINS and HOMA-IR in T2DM group were significantly higher than those in high SF group （ P 〈 0.05 ）. The SF and MCV in high SF group were significantly higher than those in control group （ P 〈 0.05 ）. Conclusions Iron overload leads to the increasing of SF, which is correlated with insulin resistance in patients with T2DM.