微量元素与前列腺癌发病危险的病例—对照研究

Studies on the relationship between prostatic cancer and trace elements:a case-control studies

目的 :为探讨血清微量元素含量与前列腺癌发病危险的关系。方法 :对 96例前列腺癌新发病例实施 1∶ 3配比的病例—对照研究。结果 :前列腺癌病例与医院非癌对照、正常对照比较 ,血清 Se(OR分别为 0 .62 ,0 .53)、Zn(OR分别为 0 .60 ,0 .58)、Cu/Zn(OR分别为 1 .70 ,1 .63)水平上差异有显著性 (P<0 .0 5) ,且与前列腺癌的发病危险存在剂量 -反应关系。结论 :提示血清 Se、Zn的降低及

Objective In order to evaluate the correlation of trace elements to prostatic cancer.Methods A hospital-based case-control study was conducted in 5 hospitals of Jinan.A total of 96 cases of histologically confirmed prostatic cancer diagnosed between 1997～1999 and 288 controls of comparable age,sex,and nationality were interviewed in the study.Results Compared the prostatic cancer cases with non-cancer cases and neighborhood controls,selenivmlor (OR=0.53～0.62),Cu/Zn(OR=1.63～1.70) were significanty related to prostatic cancer and had a dose-response relationship with the risk of prostatic cancer.Conclusions It is concluded that lackness of Selenium or Zinc and with high level of Cu/Zn may increase the risk of prostatic cancer.