羟基喜树碱、氨甲蝶呤、5-氟脲嘧啶和醛氢叶酸联合化疗治疗晚期复发性乳腺癌

Combined Chemotherapy of HCPT, MTX, Leucovorin and 5-Fu for Metastatic Breast Cancer

目的：观察包含羟基喜树碱的联合化疗方案治疗晚期复发性乳腺癌的疗效及毒副作用。方法： ４３例乳腺癌患者均为术后或放疗后、并且己行系统化疗结束后复发或转移复治的病例。化疗方案为羟基喜树碱１０ｍｇ／ｍ２静滴，第 １—５ ８；氨甲喋呤 １００ｍｇ静冲，第 １日、醛氢叶酸 １５０ｍｇ／ｍ２第 ２～ ４ 日，静滴； ５－氟脲嘧啶 ５００ｍｇ／ｍ２静滴，第１－５日；每２８日为一周期，连用两个周期以上。结果：总有效率４７％，１年生存率５４％，中位生存期为１９个月。主要毒副作用为轻度的血液和消化道反应。结论：含羟基喜树碱的ＨＭＬＦ方案是治疗晚期复发性乳腺癌有效且毒性较小的联合化疗方案。

Objective: The therapeutic efficacy and side effects of combined chemotherapy of HCPT, MTX, LV and 5 - Fu for metastatic or recurrent breast cancer were evaluated in our study. Methods: A total of 43 cases of advanced metastatic or recurrent breast cancer were treated with chemotherapy regimen consisting of HCPT 10mg/m2 iv gtt for d1 -5, MTX 100mg tv d1, Leucovorin 150mg/m2 iv gtt for d2 - 4, 5 - Fu 500mg/m2 iv gtt for d1 - 5. The cycle was repeated every 4 weeks, and 2 cycles were given as one course. Results: The overall CR + PR was 47 %. One year survival rate was 54% and the median survival interval was 19 months. The main side effects were bone marrow suppression and gastrointestinal reaction. Conclusion: The combined chemotherapy regimen consisting of HCPT etc is beneficial for metastatic breast cancer.