氨基功能化有机-无机杂化介孔材料合成及药物释放性能研究

Study on synthesis of amino functionalized organic-inorganic hybrid mesoporous materials and drug delivery property

以1,2-二(三甲氧基硅基)乙烷(BTME)和3-氨基丙基三乙氧基硅烷(AMPTS)为前驱体,通过共缩聚的方法合成氨基修饰的乙烷桥联的有序介孔氧化硅,并对其进行表征;再以布洛芬为模型药物,将得到的材料用于药物的吸附与释放,研究其药物释放性能.结果表明,氨基修饰后的杂化介孔材料对布洛芬具有更强的吸附能力,从修饰前的0.35 g/g增加至0.78 g/g.与未修饰的材料EA—0相比,氨基功能的材料EA—20在释放过程中具有更好的缓释效果.

Amino group-functionalized mesoporous ethane-silicas were synthesized by co-condensation of 1, 2-bis （ trimethoxysily ） ethane （ BTME ） and 3-aminopropyltriethoxysilane （ AMPTS ）. TEM, XRD, nitrogen adsorption and desorption, FT-IR, elemental analysis and ^13C NMR were used to characterize the obtained materials. Ibuprofen was used as a model drug to test the drug adsorption and release properties of meso- porous materials. The results showed that amino group-functionalized mesoporous ethane-silicas presented stronger adsorption capacity, which could increase up to 0.78 g/g from 0.35 g/g. Compared with EA - O, the materials EA- 20 had a better sustained release effect during the release process.