水貂自咬症病因的遗传分析策略及进展

The Genetic Analysis Strategy on Etiological Factors of Mink Self-Biting Disease

自咬症是世界范围内养殖的毛皮兽广泛流行的疾病之一,其危害主要表现在皮张质量的降低。目前对该症的发病机理和检测方法报道很少,因此早期诊断和淘汰患病个体成为防止该病发生的主要措施。从2007年起,课题组开始利用标记辅助选择或基因辅助选择等措施,寻找与水貂自咬症相关的候选基因和分子标记,共筛选出6对特异性分子标记,并发现3个候选基因的7个突变位点与自咬症的发生显著相关。文中对课题组近5年研究成果作一综述,为阐明自咬症的发病机理给予新的提示与参考。

Self-biting disease occurred in most farmed fur animal in the world caused wound to take effect on mink pelt quality. There is little information concerning the mechanism and rapid detection methods of this disease had not been reported, so to distinguish self-biting individuals from healthy ones was one of the major measures to control the disease. Our research group used Marker Assisted Selection （MAS） and gene-assisted selection （GAS） to find the molecular marker and candidate genes of self-biting disease since 2007. So far, we had found six special molecular markers and seven SNPs on three candidate genes to detect the disease. In this paper, literatures concerning recent researches on etiological factor of self- biting disease from both domestic and oversea were reviewed to provide theoretical basis for further study on molecular breeding and disease prevention of mink.