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双特异性抗体的临床应用进展

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摘要 天然的单体抗体分子具有两条相同的配基识别臂，若将其中配基识别臂替换，使其能够结合另一种配基，即成为双特异性抗体（bispecificantibody，BsAb）。早在19世纪末BsAb就被描述为专门针对微生物，而保留正常宿主细胞能力的一种化学物质。其特点是在同一抗体分子的两个抗原结合臂，可同时结合两个不同的抗原，一个与靶抗原结合；另一个与免疫效应细胞上的标志抗原结合，能在靶细胞和功能分子（细胞）之间架起桥梁，激发具有导向性的免疫反应。本文仅就BsAb临床上的应用进行简要综述如下。
作者 肖创清 黄志红
机构地区 湖南长沙解放军第一六三医院
出处 《放射免疫学杂志》 CAS 2013年第5期587-589,共3页 Journal of Radioimmanology
关键词 双特异性抗体 临床应用 文献综述 抗体分子 免疫效应细胞 BsAb 宿主细胞 靶抗原
分类号 R392-33 [医药卫生—免疫学]
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参考文献19

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放射免疫学杂志
2013年 第5期

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