组织激肽释放酶与缺血性脑卒中患者预后的相关性研究

Correlative Exploration Between Tissue Kallikrein and the Prognosis of Cerebral Ischemic Stroke

目的:探讨组织激肽释放酶(TK)与缺血性脑卒中(CIS)患者短期预后的关系。方法:采用酶联免疫吸附法检测280例CIS患者(试验组)和50例体检健康者(对照组)血浆TK,并对CIS患者进行神经功能缺损程度评分和牛津残障评分,探讨TK与其相关性。结果:①CIS患者急性期和恢复期血浆TK分别为(0.171±0.031)mg/L和(0.193±0.036)mg/L,均低于对照组(0.251±0.043)mg/L,差异有统计学意义(P<0.05);②CIS患者急性期神经功能缺损评分(22.86±3.21)显著高于恢复期(13.12±1.45),差异有统计学意义(P<0.05);③CIS患者急性期和恢复期血浆TK水平与神经功能缺损评分均显著负相关(r分别为-0.582和-0.473,均P<0.05);④预后良好组急性期和恢复期血浆TK水平分别为(0.176±0.036)、(0.198±0.040)mg/L,均相应高于对照组急性期(0.159±0.023)和恢复期(0.184±0.027)mg/L,差异均有统计学意义(P<0.05)。结论:TK水平下降预示CIS患者预后不良。

Objective To explore correlativity between tissue kallikreir, （TK） and the prognosis of cerebral ischemic stroke （CIS）. Methods The concentration of plasma TK was measured in 280 CIS patients, as well as in 60 normal healthy persens as con- trois. The function defect score and the oxford handicap scale were evalvated in the CIS patients, too. Correlative analysis was used to realize the relationship between TK and the function defect score. Results The concentration of TK in the acute stage and recovery stage in the CIS patients was （0.171± 0.031 ）mg/L and （0. 193 ± 0.036 ）mg/L respectively, and showed significantly lower than that in the control group（0.251 ±0.043） ; The function defect score in the acute stage expressed significantly higher than that of recovery stage in CIS patients（P 〈0.05） ; The TK proved significantly negative correlated with the function defect score beth in the acute stage and recovery stage（P 〈0.05）. The concentration of TK indicated significantly lower in the poor prognosis group than that in the good prognosis group both in the acute stage and recovery stage （P 〈 0.05）. Conclusion The lower concentration of TK predict poor prog- nosis in the CIS patients.