二硫化碳接触工人体内一氧化氮水平的初探

A preliminary study on body level of nitric oxide in workers exposed to carbon disulfide

目的 探讨二硫化碳 (CS2 )作业工人体内一氧化氮 (NO)水平的变化及其机制。 方法选取某化纤厂CS2 作业工人 6 0名和不接触CS2 工人 36名 ,分别测定血浆NO、脂质过氧化物 (LPO)水平及红细胞超氧化物歧化酶 (Ery SOD)活性。结果 高、低剂量接触组工人血浆NO水平分别为(4 3 2 8± 19 83)和 (5 0 0 7± 2 1 0 1) μmol/L ,与对照组 (70 6 6± 2 6 83) μmol/L比较 ,两者均显著降低 ;高、低剂量接触组工人Ery SOD活性分别为 4832 2 1和 3 5 2 0 80u/gHb ,与对照组 (2 42 5 34u/gHb)比较 ,高剂量组显著升高 ;高、低剂量接触组工人血浆LPO水平分别为 19 38和 17 0 9μmol/L ,与对照组(4 37μmol/L)比较 ,均显著增高。结论 职业性长期接触CS2 能导致体内血浆NO水平下降 ,其机制与CS2

Objective To study changes in body plasma level of nitric oxide (NO) in workers exposed to carbon disulfide (CS 2) and its possible mechanism. Methods Plasma levels of NO and lipid peroxide (LPO) and activity of erythrocyte superoxide dismutase (Ery SOD) were determined in the workers exposed and unexposed to CS 2 in a chemical synthetic fiber works. Results Level of NO was (43 28±19 83) and (50 07±21 01) μmol/L in high and low dose exposed groups, respectively, significantly lower than that in the control group, which was (70 66±26 83) μmol/L( P< 0 05). Activity of Ery SOD was 4 832 21 u/g Hb and 3 520 80 u/g Hb in high and low dose exposed groups, respectively, significantly higher than that in the control group, which was 2 425 34 u/g Hb( P< 0 05). Level of LPO was 19 38 and 17 09 μmol/L in high and low dose exposed groups, respectively, significantly higher than that in the control group, which was 4 37 μmol/L( P< 0 05). Conclusion Occupational long term exposure to CS 2 could induce reduction of NO level in the body with its mechanism related to increase of super oxygen cation O 2 induced by CS 2.