血管紧张素原基因多态性与原发性高血压关系的研究

The relationship between polymorphism of angiotensinogen gene and essential hypertension

目的 探索血管紧张素原 (AGT)的M2 35T多态性与上海市嘉定区望新乡原发性高血压的关系。方法 以人群为基础进行高血压病例 -对照研究 ,应用PCR RFLP技术 ,分析AGT的M2 35T多态性。结果 望新乡高血压病例组中AGT基因TT基因型频率显著高于对照组 ,分别为42 .8%和 33 .0 %。相对于MM基因型 ,暴露于TT基因型的OR值为 3 .6 1。病例组中T等位基因的频率也显著高于对照组 ,分别为 73 .89%和 6 0 .31% ,随着等位基因T的增加 ,患高血压的危险性显著增加 ,趋势检验P <0 .0 5。病例组中体质指数按MM、MT、TT基因型的顺序依次增大 ,各组差异有显著性。

Objective To study the renin angiotensin system (RAS) involvement in the hormonal regulation of BP and blood volume and the relationship between angiotensinogen (AGT) was the sole preliminary acting materials in the RAS. Method Population based case control study was conducted using PCR RFLP techniques to explore the relationship between the M235T polymorphism of AGT and EH in Wangxin township, Jiading District of Shanghai. Results The frequency of TT genotype in EH cases was significantly higher than in controls ( 42.8 % and 33.0 %). The odds ratio ( OR ) for those exposed to TT genotype was 3.61 , comparing with MM genotype. It was suggested that TT genotype be the susceptible genotype of EH in Wangxin. The frequency of allele T in EH cases was 73.89%, significantly higher than that of 60.31% in controls. With the increase of allele T, the risk of EH also increased ( P < 0.05 ). In EH cases, the BMI increased in the order of MM, MT and TT, and significant differences between the groups were observed. Conclusion TT genotype is the susceptible genotype of EH in Wangxin.