老年2型糖尿病患者血浆凝血因子Ⅶ检测及临床意义

Detection of plasma coagulation factor Ⅶ in old patients with type 2 diabets mellitues and its clinical significance

目的 对３６例老年２型糖尿病（２型 ＤＭ）患者进行血浆凝血因子Ⅶ水平检测，探讨临床意义。方法 ＦⅦａ测定采 用重组可溶性组织因子法；ＦⅦＡｇ测定采用 ＥＬＩＳＡ法；ＦⅦｃ采用一阶段凝固法。并计算 ＦⅦａ／ＦⅦＡｇ与 ＦⅦｃ／ＦⅦＡｇ比值。结 果 ＦⅦａ为 ２．９±０．９ｎｇ／ｍｌ，ＦⅦｃ为 １０７±２５％，ＦⅦＡｇ为 ７６±１９％，ＦⅦａ／ＦⅦＡｇ为 ３．２８，ＦⅦｃ／ＦⅦＡｇ为 １．４１，与对照组相比除 Ｆ ⅦＡｇ外，其余数据均有增高，呈显著性差异。结论老年 ２型 ＤＭ患者血液具高凝状态，有血栓形成可能，应采取防止血栓形 成的措施。

Objective To detect plasm level of coagulation factor Ⅶ in 36 old patients with noninsulin-dependent diabetes mellitus and to discuss its clinical significance. Method FⅦ was detected with recombinant soluble tissue factor method. FⅦAg was detected with ELISA. And FⅦc was detected with phase I coagulation method. Then relative value of F Ⅶa/FⅦAg and FⅦc/FⅦAg was calculated. Results FⅦa 2.9±(ng/ml), FⅦc was 107± 125 %; FⅦAg was 76±19 %; F Ⅶa/FⅦAg value was 3.82 and FⅦc/FⅦAg was 1.41.Besides FⅦAg, the others were significantly highter than these of control group. ConduSion The results of this study showed that the old patients with diabetes mellitus were inhypercoagulation state and perhaps there G possibility to form thrombosis. Therefore, we should take meausres to combat the thrombosis.