Olig基因与中枢神经系统疾病的研究进展

The progress of Olig genes and diseases of central nervous system

Olig1和Olig2是Olig家族主要成员，近年来研究发现Olig1和Olig2与脱髓鞘疾病、胶质瘤、缺血缺氧性脑损伤等疾病的发生及恢复密切相关，它们不仅参与了少突胶质早期定向分化和晚期成熟分化的转录调控过程，而且对中枢神经系统的正常发育及髓鞘的形成有着至关重要的作用。有关Olig基因与中枢神经系统疾病关系的研究成为国内外研究的热点。

Olig1 and Olig2 are Olig family major members. Recent studies have found that Olig1 and Olig2 are closely related to many diseases of central nervous system, such as demyelinating diseases, gliomas and hypoxia-ischemia brain injury. They are not only involved in the directed differentiation of precursor oligodendro- cyte and stranscriptional regulation of the maturation of oligodendrocytes, but also play vital roles in the develop- ment of the central nervous system and the formation of myelin. Therefore, the research about the relationship of Olig genes and central nervous system diseases have been focused at home and abroad.