儿科感染性疾病发生全身性炎症反应综合征和多器官功能不全综合征的临床分析

Clinical analysis of systemic inflammatory response syndrome and multiple organ dysfunction syndrome in children infectious disease

目的 观察全身炎症反应综合征 (SIRS)在儿科感染性疾病中发生的情况及导致多器官功能不全综合征 (MODS)的机率和危险因素。 方法 对 938例因单纯感染性疾病住院患儿发生SIRS和MODS的情况进行动态观察和分析。 结果 938例感染患儿中出现SIRS的共 12 5例 ,占 13 3%。SIRS组不论是单器官功能不全还是MODS的发生率均高于非SIRS组 (P <0 0 1)。符合SIRS 4项标准中的项目越多 ,发生MODS的机率越高。SIRS组患儿入院 3d内MODS的发生率 (85 7% )远高于 3d后的发生率 (14 3% )。 结论 SIRS患儿发生MODS的危险性较大 ,与符合SIRS诊断标准的项目数拟呈正比 ,SIRS患儿应早期干预、综合治疗 ,才能阻断SIRS的继续发展 。

Objective To investigate the opportunity of systemic inflammatory response syndrome(SIRS) and the risk factors of multiple organ dysfunction syndrome(MODS) in children infectious disease.Methods According to the criteria of SIRS and MODS,938 cases who was hospitalized owing to pure infectious disease were studied for the morbidity of SIRS and MODS.Results 125 cases(13 3%) were diagnosed as SIRS.Whether single or multiple organ dysfunction,the occurrence rate was higher in SIRS group than that of non SIRS group( P <0 01).The risk factors of MODS related to the four criteria of SIRS,the more cases met the criteria,the more MODS happened..Conclusion The SIRS patients have high incidence of MODS and the incidence tend to be in proportion to the number meeting of four SIRS′ criteria.We recommend that early intervention should be taken in SIRS cases,in order to avoid MODS′ developing.