全身炎症反应综合征患儿血清C-反应蛋白测定的意义

Evaluation of serum CRP in patients with SIRS

目的 了解全身炎症反应综合征 (SIRS)患儿在不同阶段血清C 反应蛋白 (CRP)测定的意义。 方法 随机选择 6 0例符合SIRS诊断的患儿 ,分别于急性期和恢复期行血清CRP测定。同时选择同期住院无SIRS的非危重病儿 30例作为对照组。观察CRP水平的改变与病情严重程度的关系及对MODS发生率的影响。 结果 SIRS患儿血清CRP水平在急性期显著升高(92 8mg/L) ,急性期与对照组 (15 1mg/L)比较有显著差异 (P <0 0 1)。SIRS患儿急性期A、B二组MODS的发生率分别为10 5 %、40 9%。 结论 CRP在SIRS的发生、发展中起重要作用 ,在SIRS急性期CRP显著增高者提示病情危重。对预测MODS的发生 。

Objective To explore the significance of serum C reactive protein(CRP) in patients with SIRS of various phases.Methods 60 patients with SIRS were randomly sampled(who fulfilled the standard of SIRS).Serum CRP was measured in acute phase and convalescence respectivly.30 patients without SIRS were chosen as the control group.The relation between CRP concentration and severity of disease to effect MODS morbidity were observed.Results The serum CRP concentration of patients with SIRS(92 8 mg/L) was significantly different to the controls(1 5 mg/L, P <0 01) and the convalescence(24 2 mg/L, P <0 01).The morbidity of MODS in patients with SIRS is 10 5% in group A and 40 9% in group B..Conclusion CRP plays an important role in the occurrence,development of SIRS.In acute phase of patients with SIRS,the high CRP concentration indicates the severity of illness.This finding provides theoretical basis for prevention and management in early stage of MODS.