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瘦素与慢性阻塞性肺疾病病情程度的相关性研究 被引量:1

The relevance of research about leptin and the degree of the chronic obstructive pulmonary disease condition
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摘要 目的:研究血清瘦素及部分临床指标(FEVl%、6分钟步行距离)与慢性阻塞性肺疾病(coPD)急性发作病情程度的相关性,探讨瘦素对慢性阻塞性肺疾病病情评估价值。方法:检测轻、中、重度c0PD急性发作期住院患者治疗前后血清瘦素、6分钟步行距离、肺功能变化,并进行统计学分析。结果:无论治疗前后,重度COPD患者血清瘦素水平明显高于轻、中度组,3组间有显著差异性(P<0.05),重度COPD患者6分钟步行距离、肺功能(FEVl%)明显低于轻、中度组,3组间有显著差异性(P<0.05),治疗后,所有患者血清瘦素与治疗前相比,有所下降,而肺功能(FEVl%),6分钟步行距离在轻、中度COPD组均有所升高,重度COPD组与治疗前相比6分钟步行距离、肺功能(FEVl%)增加不明显。结论:联合血清瘦素、6分钟步行距离、FEVl%变化可有效地评估cOPD急性发作及病情程度。 objective:To stuidy the changes and correlations between leptin and some clinical indices (FEV1% .) ,during acute exacerbation of chronic obstractive pulmonary (COPD) to explore the value of the leptin on confirming acute exacerbation and predicting their severity. Methods changes Of Leptin FEVI% predicted, 6 minutes walking distance were analyzed in subject for COPD requiring hospital admissions results durir^L AECOPD Leptin declines .When the symptoms after remission in all groups. Tihe leptin in Severe group, was higher than that of mild.moderate group (P〈0. 05),there were significant negative correlationg between leptin and FEVI% .6 minutes walking distance (r=-0.402 P〈0. 05) Conclusion: Serum leptin, 6 minutes walking distance, the change of FEVI% can effectively evaluate the acute attack of COPD and the severity of disease
出处 《内蒙古中医药》 2013年第24期40-41,共2页 Inner Mongolia Journal of Traditional Chinese Medicine
关键词 瘦素 慢性阻塞性肺疾病 6分钟步行试验 肺功能 Leptin chronic obstructive pulmonary 6 minutes walking test lung function
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