三种呼吸支持方式治疗早产儿反复呼吸暂停的疗效比较

Effects of three respiratory support methods on recurrent apnea in preterm infants.

目的观察经鼻同步间歇正压通气(NSIPPV)、经鼻持续气道正压通气(NCPAP)与吸氧治疗早产儿反复呼吸暂停的疗效。方法回顾性分析2008年6月至2012年6月在本科诊断为反复呼吸暂停的早产儿83例,根据呼吸支持方式的不同分为NSIPPV组、NCPAP组和吸氧组,三组在综合治疗的基础上分别给予NSIPPV、NCPAP和吸氧治疗,观察并比较三组的疗效。结果 NSIPPV组、NCPAP组、吸氧组的治疗总有效率分别为89.66%、64.29%、34.62%(P<0.05),显效率分别为62.07%、35.71%、7.69%(P<0.05),治疗失败应用气管插管机械通气的百分率分别为10.34%、35.71%、65.38%(P<0.05)。结论与NCPAP、吸氧相比,NSIPPV治疗早产儿反复呼吸暂停疗效更显著。

Objective To retrospectively investigate the effects of nasal synchronized intermittent positive pressure ventilation （NSIPPV）, nasal continuous positive airway pressure （NCPAP） and oxygen therapy on recurrent apnea in preterm infants. Methods From June 2008 to June 2012, 83 preterm infants with recurrent apnea were in- eluded and divided into the NSIPPV group, the NCPAP group and the oxygen therapy group according to the respirato- ry support method, which were given NSIPPV, NCPAP and oxygen therapy on the basis of the comprehensive treat- ment, respectively. The effects were compared among the three groups. Results The total effective rates of NSIPPV group, NCPAP group and oxygen therapy group were 89.66%, 64.29%, 34.62%, respectively （P〈0.05）, the markedly effective rates were 62.07%, 35.71%, 7.69% （P〈0.05）, and the percentages of mechanical ventilation with tracheal in- tubation were 10.34%, 35.71%, 65.38% （P〈0.05）. Conclusion The effects of NSIPPV treatment were more signifi- cant than other groups in preterm infants with recurrent apnea.