重组人生长激素对卵巢切除大鼠松质骨的影响

The effects of recombinant human growth hormone on cancellous bone of ovariectomized rats

目的 研究重组人生长激素对卵巢切除后已发生明显骨丢失大鼠松质骨的影响。方法 6月龄 SD雌性大鼠卵巢切除 3个月后开始接受低、中、高三种剂量重组人生长激素皮下注射 8周，采用骨密度测定、骨组织形态计量学等手段研究大鼠腰椎松质骨的改变。结果 重组人生长激素显著增加骨质疏松大鼠的骨密度，对改善松质骨骨量及骨结构参数都有显著作用。 1.0 mg· kg-1· d-1治疗组效果最佳。结论 重组人生长激素能够促进骨质疏松大鼠骨量恢复，并能够显著改善松质骨的结构，其作用效果与重组人生长激素的剂量有关。

Objective To investigate the effects of recombinant human growth hormone on cancellous bone of ovariectomized rats with remarkable bone loss. Methods Six-month old Sprague-Dawley(SD) rats were used to receive low, middle and high doses of recombinant human growth hormone three months after ovariectomy. Bone mineral density and bone histomorphormetry were used to study the alteration of cancellous bone of lumbar vertebrae. Results Recombinant human growth hormone significantly increased bone mineral density and improved the cancellous bone volume and trabecular bone architectures. Conclusion Recombinant human growth hormone can restore the bone loss in ovariectomized rats and improve the trabecular bone architectures. However, its effect is dose related.