颅内感染患者降钙素原和C反应蛋白变化及其与预后的关系

Change of serum procalcitonin and C reactive protein and their correlation with prognosis in patients with intracranial infection

目的探讨颅内感染患者血清降钙素原和C反应蛋白变化及其与预后的关系。方法选取2009年1月到2012年12月我院收治的51例颅内感染患者作为研究对象,并选择同期我院体检的34例健康者作为对照组,分析两组血清中降钙素原和C反应蛋白的变化。51例患者根据预后分为治愈组、好转组和加重/死亡组,分析降钙素原和C反应蛋白水平与预后的关系。结果与对照组比较,观察组患者血清降钙素和C反应蛋白水平明显增加,差异有统计学意义(P<0.05)。与加重/死亡组比较,治愈组和好转组血清降钙素原和C反应蛋白水平明显下降,差异有统计学意义(P<0.05)。治愈组血清降钙素和C反应蛋白水平明显低于好转组,差异有统计学意义(P<0.05)。结论血清降钙素和C反应蛋白水平可作为临床颅内感染诊断和预后判断的辅助指标。

Objective To explore the change of serum proealcitonin and C reactive protein and assessing their prognostic value in patients with intracranial infection. Methods Fifty-one patients with intracranial infection from January 2009 to December 2012 in our hospital were selected as the study subjects （the study group）, and 34 healthy individuals at the same time were selected as the control group. Procalcitonin and C reactive protein in serum were determined. The 51 patients were divided randomly into the cure group, the improved group and the worse/death group. The relationship between procalcitonin, C reactive protein and prognosis were analyzed. Results Compared with the control group, procalcitonin and C reactive protein in serum were significantly increased in the study group （P〈0.05）. Compared with the worse/death group, procalcitonin and C reactive protein in serum significantly reduced in the cure group and the improved group （P〈0.05）. Procalcitonin and C reactive protein in the cure group significant- ly reduced than that in the improved group （P〈0.05）. Conclusion Serum procalcitonin and C reactive protein level can be used as auxiliary indexes for clinical diagnosis and prognosis ofintracranial infection.