雄激素补充对更年期男性心理及生活质量的影响研究

Impact of Androgen Replacement on Psychological Condition and Quality of Life in Climacteric Males

目的观察雄激素补充治疗是否可以改善更年期男性的心理状况并提升患者生活质量。方法将受试者采用双盲随机法分至治疗组及对照组,并分别于治疗前和治疗后3个月完成以下量表:医院焦虑抑郁量表(HADS)、压力知觉量表(PSS)和健康相关生活质量量表(SF-12)。治疗组患者每日口服120～160 mg十一酸睾酮(TU),对照组仅服用维生素C。每两周随访一次,观测心理状况的变化及服用后有无副作用。结果治疗组与对照组治疗前各项指标比较差异均无统计学意义(P<0.05)。治疗组与对照组治疗后睾酮浓度〔(395±34)μg/L比(231±27)μg/L〕差异有统计学意义(P<0.05);HADS焦虑评分分别为(3.5±0.4)分和(1.7±0.2)分,差异有统计学意义(P<0.05);HADS抑郁评分分别为(4.9±0.6)分和(2.4±0.3)分,差异有统计学意义(P<0.05);PSS评分分别为(12.9±2.1)分和(9.8±1.7)分,差异有统计学意义(P<0.05);SF-12评分分别为(56.1±7.3)分和(52.1±7.0)分,差异有统计学意义(P<0.05)。结论雄激素补充治疗可改善更年期男性心理负担并提升患者生活质量。

Objective To investigate whether androgen replacement therapy can improve the psychological condition and quality of life in males in their climacteric stage.Methods Eligible subjects were randomized into trial and control group,and were asked to complete the following questionnaires at baseline and after 3-month treatment： AMS rating scale,Hospital Anxiety and Depression Scale（HADS）,Perceived Stress Scale（PSS） and The Short Form Health Survey-12（SF-12）.In this study,the subjects in the trial group were treated and monitored for 3 months with oral testosterone undecanoate（TU） capsules,120 ～ 160 mg daily;while those in the control group were only given vitamin C.All the subjects were followed up every two weeks to observe their changes in psychology and side effects of the drugs.Results The difference between the two groups in serum testosterone concentration after the intervention 〔（395 ± 34） μg/ L vs.（231 ± 27） μg/ L〕was statistically significant（P 0.05）;and so was in anxiety score of HADS 〔（3.5 ± 0.4） vs.（1.7 ± 0.2） 〕,in depression score of HAD 〔（4.9 ± 0.6） vs.（2.4 ± 0.3） 〕,in PSS score 〔（12.9 ± 2.1） vs.（9.8 ± 1.7） 〕 and in SF-12 score 〔（56.1 ± 7.3） vs.（52.1 ± 7.0） 〕（P 0.05）.Conclusion Androgen replacement therapy can improve both psychological issues and quality of life in males in their climacteric stage.