谷胱甘肽S-转移酶M1和T1基因多态性与白癜风易患性关系的Meta分析

Glutathione S-transferase M1 and T1 Genetic Polymorphisms and Vitiligo Susceptibility: A Meta-analysis

目的探讨谷胱甘肽S-转移酶(GST)M1和T1基因多态性与白癜风易患性的关系。方法检索Pubmed、Embase、中国知网(CNKI)、维普、万方数据平台从建库到2013年3月的文献,收集符合本Meta分析纳入标准和排除标准的病例对照研究,运用Review Manager 5.0.0软件(Cochrane网提供)进行Meta分析。结果共纳入4篇文献,累计样本量为2 781例,其中病例组1 218例,对照组1 563例。Meta分析显示,GSTM1和GSTT1基因多态性与白癜风易患性的关联有统计学意义〔基因型GSTM1空白对GSTM1非空白:OR=1.50,95%CI(1.12,2.02),P=0.007;基因型GSTT1空白对GSTT1非空白:OR=1.30,95%CI(1.12,1.52),P=0.0008;基因型GSTM1空白/GSTT1空白对GSTM1/GSTT1非空白/非空白:OR=1.62,95%CI(1.25,2.11),P=0.0003〕。结论 GSTM1、GSTT1基因多态性与白癜风相关,GSTM1空白基因型和GSTT1空白基因型可能增加白癜风的发病,且两者对增加白癜风发病具有协同作用。

Objective To investigate the association between glutathione S -transferase M1 （GSTM1） and T1 （GSTTl） polymorphisms and vitiligo susceptibility. Methods Pubmed, Embase, CNKI, VIP, and Wanfang Data before March 2013 were searched to get case control studies. Meta - analysis was conducted by using Revman 5.0. 0 software. Results Four case - control studies with 1 218 patients and 1 563 healthy controls were included. Meta - analysis showed there are signifi- cant differences between GSTM1, GSTY1 and vitiligo susceptibility [GSTM1 Null vs. GSTM1 Present： OR = 1.50, 95% CI （ 1.12, 2.02）, P = 0.007 ; GSTI？I Null vs. GSTI＇I Present： OR = 1.30, 95% CI （ 1.12, 1.52）, P = 0. 0008 ; GSTM1/ GSTI＇I Null/Null vs. GSTM1/GSTrl Present/Present： OR = 1.62, 95% CI （1.25, 2. 11 ）, P = 0. 0003 ] . Conclusion GSTM1 and GSTY1 polymorphisms are related with vitiligo susceptibility, Null genotypes of GSTM1 and GSTY1 may increase the risk of vitiligo, and they may enhance the risk of vitiligo synergistically.