通脉消斑汤对颈动脉粥样硬化患者血清可溶性细胞黏附分子的影响

Effect of Tongmai Xiaoban Decoction on Level of Serum Soluble Cell Adhesion Molecules in Carotid Atherosclerosis

目的观察通脉消斑汤对颈动脉粥样硬化(CAS)患者血清可溶性细胞黏附分子(sICAM-1)水平的影响,探讨通脉消斑汤抗动脉粥样硬化的作用及其作用机制。方法选择CAS患者100例,随机分为两组,通脉消斑汤(TD)组50例和阿托伐他汀(AC)组50例,分别用通脉消斑汤和阿托伐他汀钙进行治疗6个月,对两组CAS患者血清sICAM-1和可溶性血管细胞黏附分子-1(sVCAM-1)进行检测。结果与治疗前比较,治疗后TD组与AC组sICAM-1、sVCAM-1水平均明显降低(P<0.01),治疗后比较两组间无统计学意义。结论通脉消斑汤可以显著降低CAS患者血清sICAM-1、sVCAM-1,通脉消斑汤可能通过调节可溶性细胞黏附分子水平来发挥抗AS的作用。

Objective To investigate the effect of Tongmai Xiaoban decoetion（TXD） on the level of serum soluble intercellular ad- hesion molecule- 1 （sICAM- 1） and soluble vascular cell adhesion molecule- 1 （sVCAM- 1 ） in carotid atheroselerosis （GAS）, and to explore its mechanism. Methods One hundred patients with CAS were randomly divided into 2 groups： TXD group （n： 50） and atorvastatin calcium （AC）group （n=50）. The level of soluble cell adhesion molecules were observed before and after treatment. Results The serum level of sICAM - 1 and sVCAM - 1 in CAS patients were obviously decreased in TXD group（P〈0.01） and AC group （P〈0.01）. Conclusion TXD could decrease the level of sICAM - 1 and sVCAM - 1 in CAS patients. The effect of TXI） a gainst AS might be related with its decreasing the serum level of soluble cell adhesion molecules.