九味镇心颗粒治疗中风后焦虑临床观察

Clinical Observation on Jiuwei Zhenxin Granules for Treatment of Post-stroke Anxiety Disorder

目的探讨九味镇心颗粒对中风后焦虑(PSAD)的治疗作用。方法 64例PSAD患者随机分为两组,治疗组与对照组各32例。治疗组口服九味镇心颗粒,对照组口服黛力新。基础治疗相同,同时进行心理护理、疏导及支持。以汉密尔顿焦虑量表(HAMA)对患者的焦虑程度及改善状况进行评定,并将疗效和安全性作对比。结果 HAMD评分两组治疗前后对比,均有统计学意义(P<0.05),治疗后两组间比较无统计学意义(P>0.05)。两组总有效率分别为81.25%、84.37%,比较无统计学意义(P>0.05);不良反应发生率为18.75%、73.75%,比较有统计学意义(P<0.01)。结论九味镇心颗粒治疗PSAD安全有效。

Objective To probe the effect of Jiuwei Zhenxin granules（JZG） for treatment of post - stroke anxiety disorder. Methods Sixty-four patients with poststroke anxiety disorder were randomly divided into two groups：Treatment group （n 32） treated with JZG and control group （n： 32） treated with Deanxit. The scores of Hamilton Anxiety Scale （HAMA） and Treatment Emergent Symptom Scale（TESS） were observed. Results There were significant differences in the HAMA scores before and after treatment between both groups, but there were no significant differences between two groups. There were no significant differences between the overall response rates in the two groups. There were significant differences in the side effects between both groups（P〈0.05）. Conclu sion JZG could be used treat post - stroke anxiety disorder.