氟伐他汀对骨质疏松大鼠血清E_2、TNF-α、IGF-1及BGP水平的影响

Effects of fluvastatin on serum E_2,TNF-α,IGF-1 and BGP in experimental osteoporosis rats

目的分析氟伐他汀对骨质疏松大鼠血清雌二醇(E2)、肿瘤坏死因子-α(TNF-α)、胰岛素样生长因子-1(IGF-1);及血清骨钙素(BGP)水平的影响。方法采用去势法复制骨质疏松大鼠动物模型,同时给予不同剂量的氟伐他汀(20、10、5mg/kg)进行干预,12周后,大鼠称重后处死,摘取子宫称湿重,计算子宫指数,同时取血清测定E2、TNF-α、IGF-1及BGP的浓度。结果氟伐他汀各给药组对骨质疏松大鼠子宫重量无影响;氟伐他汀20mg/kg可使骨质疏松大鼠血清E2、IGF-1水平升高(P<0.05),TNF-α及BGP水平降低(P<0.01);氟伐他汀10mg/kg可使骨质疏松大鼠BGP水平下降。结论氟伐他汀可升高骨质疏松大鼠血清E2、IGF-1水平,并降低TNF-a及BGP。

Objective To investigate the effects of fluvastatin（Flu） on the levels of estradiol（E2） ,tumor necrosis factor-α（TNF- α） ,insulin-like growth factor-1（IGF-1） and bone glaprotein（BGP） in experimental osteoporosis rats. Methods The model of osteo- porosis was established,all rats were ovarieetomized. The rats were given Flu（20,10,5 mg/kg） through intragastric administration （ig）. After treating for 12 weeks, weighed all rats, then sacrificed all rats, removed the uterus and weighed its wet weight, and calcu- lated uterus index;the levels of E2 ,TNF-α,IGF-1 and BGP in serum were detected. Results Flu did not affect the uterus weight in experimental osteoporosis rats;20 mg/kg Flu could increased the osteoporosis rat＇s serum levels of E2 and IGF-1 （P〈 0.05）, de- creased the levels of TNF-α and BGP（P〈0.01） ;10 mg/kg Flu could decreased the osteoporosis ratfs serum levels of BGP. Conclu- sion Flu could increased the levels of E2 ,IGF-1,and decreased the levels of TNF-α,BGP in experimental osteoporosis rats.