2,3-二氨基吡啶的合成研究

Synthesis of Pyridine-2,3-diamine

氨基吡啶类化合物是重要的有机化工原料，是合成许多精细化学品的中间体，在农药、医药、高分子及含能材料等领域有广泛的应用。对氨基吡啶类化合物的合成研究非常有意义。文章介绍了标题化合物的合成方法。以2，6-二氯吡啶为起始原料，经硝化、氨基取代、还原3步反应合成了目标化合物，并经MS和1_HNMR对其结构进行了表征。本合成路线原料廉价易得、反应条件温和、操作方便，是一种适合于工业化生产的新方法。反应的总收率57％。

Amino pyridines were important chemical materials and intermediates, which were widely used in pharmacy, energetic and polymer- materials industry. Therefore, the research about their synthetic routes was still in great desire. The approach to synthesize the title compound was introduced, which was realized and manufactured from 2, 6- dichloropyridine via three steps. Its structure was verified by MS and I H NMR. This synthetic route had the advantages of convenient operation and mild reaction conditions. The total product yield was 57%. This program was suitable for industrial production.