华法林治疗20例骨损伤所致血栓病人的回顾性研究

Retrospective study of 20 cases of thromboembolism in bone trauma treated by warfarin

目的:探讨抗凝药物华法林对骨损伤所致血栓的治疗是否有效和安全。方法:回顾性研究骨科病房20例经华法林治疗的深静脉血栓和/或肺动脉栓塞病人情况。结果:血栓的诊断在入院后平均13.5±3.4d被确诊。其中肺动脉血栓8例,深静脉栓塞12例,多普勒超声确诊11例,CT确诊有9例。抗凝治疗后约25 d,5例病人血栓完全消失,剩下15例的栓体大小有了明显减小,无并发症发生。结论:华法林治疗对于骨损伤病人所致深静脉和肺动脉血栓形成有较好的疗效,并能抑制并发症的产生。

Objective： To study the therapeutic efficacy and safety of warfarin in patients with venous thromboembolism in bone trauma. Methods： 20 orthopedic patients with deep venous thromboembolism and/or pulmonary embolism treated with warfarin were retrospectively studied. Results： Thrombosis was diagnosed at an average of 13.5 ± 3.4 days after admission. Thrombus formation was confirmed in pulmonary arteries in 8 cases and in deep veins in 12 cases. Diagnosis was based on Doppler ultrasound findings in 11 cases and on computed tomography findings in 9 cases. Approximately 25 days after starting anticoagulant therapy, 5 thrombi disappeared and 15 thrombi reduced in size. Conclusions： Warfarin therapy clears deep vein and pulmonary artery thrombosis in bone trauma without any bleeding complications.