呼出一氧化氮监测联合变应原皮肤点刺试验在儿童哮喘诊治中的应用性研究

Application of exhaled nitric oxide monitoring combined with allergen skin prick test in children with asthma

目的研究呼出一氧化氮监测联合变应原皮肤点刺试验在儿童哮喘诊治中的应用价值。方法选取72例哮喘患儿与同期72例正常儿童,对比其呼出一氧化氮指标及哮喘患儿变应原皮肤点刺试验结果;观察患儿治疗前后呼出一氧化氮变化情况。结果治疗前患儿组呼出气一氧化氮浓度明显高于正常组,治疗后该浓度明显下降;患儿对12种变应原均存在一定程度的过敏反应,其中屋尘螨及粉尘螨总阳性率最高。结论呼出一氧化氮及变应原皮肤点刺试验能够有效指示儿童哮喘的发生,在指导治疗中起到关键作用。

Objective To study the application value of exhaled nitric oxide monitoring combined with allergen skin prick test in children with asthma. Methods 72 children with asthma were taken as the test group and another 72 healthy children as the normal group. Exhaled nitric oxide in children with asthma and allergen skin prick test results were compared between the two groups before and after the treatment. Results Before the treatment, the concentration of exhaled nitric oxide was significantly higher in the test group than in the normal group, and it decreased obviously in the test group after the treatment. There existed a certain degree of allergic response to 12 kinds of allergens, which the dust mite showed the highest positive rate. Conclusion Monitoring of exhaled nitric oxide and allergen skin prick test can effectively indicate the development of childhood asthma, which play a key role in the treatment therapy.