血管平滑肌细胞与血管性病变发生的分子成像研究进展

Advance in molecular imaging research of vascular smooth muscle cells in the vascular diseases

血管平滑肌细胞(VSMC)是构成血管壁结构及维持血管张力的主要细胞,在血管再狭窄、动脉粥样硬化等多种血管病变中发挥着关键作用。随着分子影像学的发展,血管平滑肌细胞层面的分子成像研究日益受到重视。对VSMC在病理状态下的表型转化、增殖、迁移及分子成像研究进展予以综述,旨在提高对血管再狭窄及动脉粥样硬化形成等血管性疾病的诊治水平。

Vascular smooth muscle cells （VSMCs） are the primary cells within the vascular wall structure and maintain the tension of blood vessels, playing a key role in the restenosis, atherosclerosis and some other vascular diseases. With the development of molecular imaging, VSMCs cellular level of imaging studies is becoming more and more attention. The phenotype modulation, proliferation, migration and molecular imaging research progress of VSMCs in pathologic state were reviewed, to improve the management of vascular restenosis and atherosclerosis. [