恶性血液病患者的血浆同型半胱氨酸和血清叶酸水平的临床研究

Clinical research on Hcy and FA levels of patients with hematologic malignancies

目的探讨血浆同型半胱氨酸(Hcy)和血清叶酸(FA)水平与恶性血液病患者的关系。方法采用电化学发光法检测86名恶性血液病患者血浆中Hcy浓度、血浆叶酸、维生素B12的浓度。其中急性白血病63例,恶性淋巴瘤8例,多发性骨髓瘤8例;慢性粒细胞白血病慢性期(CML-CP)7例。并同时检查健康成人30名作为正常对照。结果急性白血病、恶性淋巴瘤、多发性骨髓瘤、慢性白血病患者组中血浆Hcy水平显著高于健康对照组(P<0.05),而FA水平明显降低(P<0.05)。结论高同型半胱氨酸血症可能是恶性血液病患者的危险因素。

[ Objective ] To investigate the relationship between patients with hematologic malignancies and levels of homocysteine （ Hcy） and folate （FA）. [ Methods] Electrochemiluminesceuce was adopted to detect plasma Hcy, FA and Vitamin B12 levels of 86 patients with hematologic malignancies. Sixty three cases had acute leukemia, 8 suffered from malignant lymphoma and 8 of multipie myeloma. Seven cases had CML-CP. Thirty healthy adults were taken as control group. [ Results] Plasma Hey levels of patients with acute leukemia, malignant lymphoma, multiple myeloma and chronic leukemia were significantly higher than those of control group （ P 〈 0. 05 ）, on the contrary, FA levels were significantly lower than those of control group I P 〈 0. 05 ）. [ Conclusion ] The hyperhomocystinemia may be a risk factor for hematologic malignancies.