超声造影在前列腺良恶性肿瘤的临床研究

Clinical Research on Contrast-enhanced Ultrasonography Used in Prostate Benign and Malignant Tumors

目的:观察超声造影参数在前列腺良恶性肿瘤的曲线特征,分析超声造影参数在鉴别前列腺良恶性疾病的临床应用价值。方法:60例前列腺特异性抗原增高患者,经前列腺穿刺活检病理结果分为良性前列腺增生(28例)和前列腺癌(32例)组;采用SonoVue造影剂行超声造影,动态观察造影全过程,绘制时间-强度曲线对前列腺增生、前列腺癌曲线进行定量分析,对造影可疑区域实施穿刺活检(6+X)。结果:前列腺癌峰值强度大于前列腺增生峰值强度(P<0.05),两者之间存在统计学差异,上升支斜率前列腺癌大于前列腺增生(P<0.05),两者之间存在统计学差异,在开始显影时间、达峰值强度时间(P>0.05),两者之间均无明显统计学差异。结论:超声造影动态观察前列腺良恶性病变血流灌注动态变化过程,且对超声造影参数进行定量分析,有助于前列腺良恶性肿瘤的鉴别诊断。

Objective：Study on the basic feature of contrast-enhanced ultrasonography parameter in prostate benign and malignant tumors and evaluate the clinical applied value of contrast-enhanced ultrasonography parameter in prostate benign and malignant tumors. Methods：Studied on 60 cases of patients with high and tubercle, and according to pathological results of transrectal prostatic biopsy, classified them as two groups of prostatic hyperplasia（28cases） and prostatic cancer（32cases）;Using SonoVue contrast agent dynamic observation of contrast-enhanced ultrasound, contrast the entire process, rendering time intensity curve of prostatic hyperplasia, prostate cancer curve to undertake quantitative analysis, to contrast the suspicious area implementation of biopsy （ 6＋X ）. Results：Postate cancer peak strength is greater than prostatic hyperplasia （P〈0.05）, then statistics difference will exist between them;base-to-peak ascending slope prostatic cancer is greater than prostatic hyperplasia（P〈0.05）, then statistics difference will exist between them as well. At the time of develop begins and peak intensity（P〉0.05）, there is no obvious statistics difference. Conclusion：Observe prostatic cancer and postatic hyperplasia blood perfusion by contrast-enhanced ultrasonography dynamically, study contrast-enhanced ultrasonography parameter by quantitative analysis, which will help prostate benign and malignant tumors’ identify and diagnosis.