乙肝免疫球蛋白联合乙肝疫苗阻断HBV母婴传播效果观察

Effect Observation of Hepatitis B Immunoglobulin Combined with Hepatitis B Vaccine in Blocking Mother-to-child HBV Transmission

目的:对乙肝疫苗结合乙肝免疫球蛋白在HBV母婴传播中的阻断效果进行分析。方法:将68例检查发现的HBsAg阳性产妇分成观察组和对照组各34例。对照组产妇与所生新生儿不作特殊乙肝预防处理,观察组产妇及其新生儿采用乙肝免疫球蛋白联合乙肝疫苗干预法,比较两组新生儿的HBsAg阳性率、抗-HBs阳性率差异。结果:观察组新生儿的HBsAg阳性率显著低于对照组,抗-HBs阳性率显著高于对照组(P<0.05),两组有统计学差异。结论:乙肝免疫球蛋白联合乙肝疫苗可以有效阻断HBV的母婴传播,保障新生儿安全。

Objective：To analyze the effects of the hepatitis B immune globulin and hepatitis B vaccine in blocking of HBV mother-to-child transmission.Methods：That 68 HBsAg positive mothers are discovered to be of HBsAg are divided into two groups.They are the observated group and the controlled group.The controlled group that are inclued the positive mothersd and their new-borned babies do not have a specific hepatitis B prevention treatment, and the other group are opposite.Results：The observated group of neonatal HBsAg positive are significantly lower than the controlled group, the positive rate of-HBs are significantly higher than the controled group （ P〈0.05 ）, there is significant difference in two groups. Conclusion：The hepatitis B immunoglobulin combined with the hepatitis B vaccine can effectively block mother-to-child transmission of HBV and guarantee the safety of newborn.