左氟沙星联合阿莫西林的序贯疗法治疗幽门螺旋杆菌感染的临床疗效分析

ClinicalAnalysis of Sequential Therapy of Levofloxacin Combined with Amoxicillin to Treat Helicobacter Pylori Infection

目的:分析含有左氟沙星和阿莫西林组成的的10d序贯疗法治疗幽门螺旋杆菌感染的临床疗效。方法:回顾我院自2009年至2012年收治的256例由胃镜检查诊断出患有胃炎或者胃溃疡的患者临床资料,将256例患者随机分为对照组和试验组,试验组为128例患者,前3d给与患者兰索拉唑,克拉霉素,阿莫西林;后7d给予患者兰索拉唑,阿莫西林,左氟氧沙星。记录患者幽门螺旋杆菌的根除率,并进行分析。对照组为128例患者,采用标准三联法,用药为兰索拉唑,克拉霉素和阿莫西林。记录患者幽门螺旋杆菌的根除率,并进行分析。结果:经过对比分析发现,采用含有左氟氧沙星和阿莫西林联合的序贯疗法的根除率为92.97%远高于采用阿莫西林的三联法的65.63%,差异明显,具有统计学意义,P<0.05。结论:含有左氟氧沙星和阿莫西林的序贯疗法在治疗幽门螺旋杆菌感染的疗效非常好,值得临床大力推广。

Objective：To analyze the clinical effects of sequential therapy of levofloxacin combined with amoxicillin to treat Helicobacter pylori infection.Methods：The clinical data from 256 cases of patients in our hospital from 2009 to 2012 were analyzed, which were diagnosed with gastritis or gastric ulcer. The 256 cases were randomly divided into the experiment group and the control group. The experiment group had 128 patients, who were given lansoprazole, clarithromycin, amoxicillin at the first 3 days and in the following 7 days they would be given lansoprazole, amoxicillin, levofloxacin levofloxacin. The eradication rate of Helicobacter pylori were noted and analyzed. The control group had 128 patients, who were treated with the standard triple therapy using lansoprazole, clarithromycin and amoxicillin. The eradication rate of Helicobacter pylori were noted and analyzed. Results：Through compare and analysis, we found that the eradication rate of sequential therapy of levofloxacin combined with amoxicillin was 92.97%,which was higher than the triple therapy of amoxicillin with 65.63%;with obvious differences, it has statistical significance P〈0.05. Conclusion：It has good curative effects to treat Helicobacter pylori infection with sequential therapy of levofloxacin combined with amoxicillin, which is worthy of clinical promotions.