地佐辛在妇科腹腔镜手术的应用

Pholcodine in Gynaecological Laparoscopic Surgery

目的:研究地佐辛应用于妇科腹腔镜手术术后病人的镇痛效果。方法:选择60例择期ASAⅠ-Ⅱ级拟行妇科腹腔镜手术治疗(手术时间<3h)患者,随机分为治疗组和对照组,每组30例。治疗组:手术结束前15分钟肌注地佐辛注射液0.1mg/kg;对照组:不用任何药物进行镇痛治疗。术后随访8h,观察镇痛效果及不良反应发生情况。结果:治疗组术后(2、4)h疼痛评分、Ramsay评分均低于对照组(P<0.01),术后8h疼痛评分低于对照组(P<0.01),Ramsay评分无统计学差异(P>0.05),两组均有恶心呕吐不良反应,差异无统计学意义。结论:地佐辛应用于妇科腹腔镜手术,能有效缓解术后切口疼痛,且术后苏醒迅速、安全。

Objective：To study the analgesic effect with pholcodine after the patient with gynaecological laparoscopic surgery. Methods：Sixty patients（the ASAⅠ-Ⅱ,surgery time〈3h） who underwent the gynaecological laparoscopic surgery were randomly divided into pholcodine group and control group,30 cases in each group. Pholcodine group：Intramuscular injection of pholcodine 0.1mg/kg at 15 minutes before the end of surgery;Control group：Analgesic treatment without any drugs. Analgesic efficacy and adverse events were observed for 24h after gynaecological laparoscopic surgery.Results：Pain scores and Ramsay scores were lower in pholcodine group after 2,4 h than the control group （P〈0.01）, pain scores were lower in pholcodine group after 8h,than the control group （P〈0.01）,Ramsay score was no significant difference （P〉0.05）.Nausea and vomiting adverse reactions occurred in two groups,no significant difference between. Conclusion：Pholcodine to assist applied in gynecological laparoscopic surgery, can effectively alleviate postoperative pain of incision, postoperative wake up quickly, and security.