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Wnt信号通路与女性生殖

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摘要 Wnt信号通路因其启动蛋白为Wnt蛋白而得名。Wnt信号通路是细胞发育和调节生长的一个关键途径，通过Wnt基因编码的Wnt蛋白与膜上相应受体结合引起细胞浆内13-catenin转入细胞核，激活相关基因转录。在正常情况下对胚胎的生长发育起着重要作用。当该途径异常时，会导致多种疾病的发生。最近研究又表明Wnt信号通路与女性生殖密切相关。本文对经典的Wnt信号通路、Wnt信号通路与女性生殖系统的早期发育、Wnt信号通路与妊娠期相关疾病以及Wnt信号通路对正常妊娠建立的影响等方面的最新研究进展进行综述。
作者 肖淼淼 肖辉雪
机构地区 华中科技大学同济医学院附属同济医院第二临床学院 中山大学护理学院
出处 《中国生育健康杂志》 2013年第5期435-437,共3页 Chinese Journal of Reproductive Health
关键词 WNT信号通路 女性生殖 胚胎植入 子痫前期
分类号 R73-37 [医药卫生—肿瘤]
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参考文献28

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二级参考文献68

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中国生育健康杂志
2013年 第5期

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