百草枯中毒患者血清细胞因子与抗氧化能力相关性分析

The correlation analysis of serum cytokines and anti-oxidative capacity in patients with paraquat poisoning

目的探讨百草枯中毒(Paraquat posisoning,PQP)患者血清细胞因子与抗氧化能力相关性。方法检测PQ患者血清白细胞介素-2(IL-2)、白细胞介素-8(IL-8)、肿瘤坏死因子-α(TNF-α)水平,及超氧化物歧化酶(SOD)、谷胱甘肽过氧化物酶(GsH-Px)、丙二醛(MDA)含量,并进一步进行比较分析。结果 PQP患者血清IL-2、IL-8及TNF-α明显高于正常人群,差异具有统计学意义(P<0.05);PQP患者GSH-px和SOD活性明显降低,而血清MDA水平明显增高,差异具有统计学意义(P<0.05);PQP患者IL-2、IL-8和TNF-α含量与SOD、GSH-px之间存在负相关(P<0.05),与MDA间存在正相关(P<0.05)。结论 PQP患者细胞因子水平随机体抗氧化能力的降低而升高。

Objective To explore the correlation of serum cytokines and anti-oxidative capacity in patients with paraquat poisoning（PQP）. Methods The serum interleukin-2 （IL-2）, interleukin -8 （IL-8）, tumor necrosis factor-α （TNF-α）levels, and superoxide dismutase （SOD）, glutathioneglutathione peroxidase （GsH -Px）, malondialdehyde （MDA）content of PQP patients were detected, and further was analyzed. Results The serum IL-2,IL-8 and TNF-α of PQP patients was significantly higher than the normal population,the difference was statistically significant （P 〈 0.05 ）; The GSH-px and SOD activity of PQP patients was significantly decreased,the serum MDA levels were significantly increased,the difference statistically significant （P 〈 0.05）;There was a negative correlation of IL-2, IL-8 and TNF-o~ and the activities of SOD, GSH-px in PQP patients （P 〈 0.05）, and a positive correlation with MDA （P 〈 0.05）. Conclusion The level of cytokine in PQP patients can elevate with the decrease in the body＇s antioxidant capacity.