行根治性手术胃癌患者预后的多因素分析

Multivariate analysis of prognostic factors in patients with gastric carcinoma treated by radical resection

目的探讨影响行胃癌根治性手术患者的预后影响因素。方法选取行胃癌根治性手术的202例患者为研究对象。单因素分析采用Log-rank法,多因素分析采用Cox风险模型。结果单因素分析显示:Borrmann分型、病理组织学类型、pTNM分期、浸润深度和淋巴结转移情况对患者生存率有显著性影响;多因素分析显示以上五项因素对生存率均有独立影响。结论 Borrmann分型、病理组织学类型、pTNM分期、浸润深度和淋巴结转移情况可作为独立危险因素。综合评估影响因素可以对患者的术后治疗、评估预后和复发转移监测提供科学准确的意见。

Objective To explore the prognostic factors in patients with gastric carcinoma treated by radical resection. Methods A total of 202 cases with gastric carcinoma were selected in our hospital as research objects who were treated with radical resection. Log-rank method was used for univariate analysis. Cox regression model was used for multivariate analysis. Results Univariate analysis showed that the Borrmann type, the histopathological type, the pTNM stage, depth infiltration and lymph node metastasis were the factors which affected the postoperative cumulative sur- vival rate significantly. Multivariate analysis showed that the above five factors were independent prognostic factors of gastric carcinoma. Conclusion The Borrmann type,the histopathological type, the pTNM stage, depth infiltration and lymph node metastasis are the unaided risk factors. Comprehensive evaluation of influence factors to postoperative treatment, prognosis assessment, monitoring of recurrence and metastasis provide more scientific and accurate suggestion.