慢性病毒性肝炎临床与病理诊断的对照研究

Control study of clinical and pathological diagnosis on chronic viral hepatitis

目的对慢性病毒性肝炎患者的临床与病理诊断进行对比分析。方法选取122例慢性病毒性肝炎患者,检测临床七项实验室指标以及组织病理学的炎症程度,比较两种方法的检测结果,并进行统计学分析。结果实验室检查的七个指标随着肝炎的炎症程度加重而呈现出相应的变化趋势,重度肝炎组别与轻、中度肝炎组相比,差异均具有统计学意义(P均<0.05);总胆红素(TBIL)、血清白蛋白(ALB)、凝血酶原活动度(PTA)三项指标之一异常患者与组织病理学检查为轻、中、重度肝炎患者的符合率分别为94.91%、63.83%和81.25%。结论实验室检测指标可以对慢性病毒性肝炎进行初步的诊断,但是疾病的确诊需要结合临床、病原学以及病理学的检查进行综合分析。

Objective To observe the control study of clinical and pathological diagnosis on chronic viral hepatitis. Methods Seven laboratory indicators and pathological inflammation were examined in 122 chronic viral hepatitis patients. The results of two methods were compared, and statistical analysis. Results Seven laboratory indicators were showed a close correlation with the degree of pathological inflammation, the indicators were significant differences （P all 〈 0.05） among severe hepatitis group with mild and moderate hepatitis groups. Coincidence rates between one of the three indicators and pathological diagnosis were 94.91%, 63.83% and 81.25% among the mild, moderate and severe groups respectively. Conclusion Preliminary diagnosis with chronic viral hepatitis can be taken from laboratory indica tors. But a comprehensive judgment for chronic viral hepatitis should combined clinical, etiological, and pathological results.