儿童急性免疫性血小板减少症46例临床分析

Clinical analysis of 46 children with acute immune thrombocytopenia

目的探讨儿童急性免疫性血小板减少症(ITP)的诊断及治疗。方法回顾性分析46例急性ITP患儿的资料,分别测定治疗组、观察组和对照组的血小板(PLT)计数、平均血小板体积(MPV)、血小板分布宽度(PDW)。结果①治疗组ITP患儿治疗前PLT计数明显低于对照组,而MPV、PDW明显高于对照组,差异均有极显著统计学意义(P<0.01);治疗后PLT计数明显上升,MPV、PDW下降,差异均有极显著统计学意义(P<0.01)。②观察组ITP患儿观察前PLT计数明显低于对照组,而MPV、PDW明显高于对照组,差异均有极显著统计学意义(P<0.01);观察后PLT计数明显上升,PDW下降,差异均有统计学意义(P<0.05),MPV有所下降,差异不具有显著性(P>0.05)。结论儿童急性ITP是一种自限性良性疾病,恢复快,预后好,应避免过度检查及治疗。

Objective To explore the diagnosis and treatment of childhood acute immune thrombocytopenia （ITP）. Methods The date of the 46 cases with childhood acute ITP were analyzed retrospectively. Platelet （PLT） counts, mean platelet volume （MPV）, platelet distribution width （PDW） in different group were detected on different stages. Results ①PLT counts in treatment group before treatment were significantly lower than that in control group, while MPV, PDW was significantly higher than that in control group, the differences between two groups were statistically significant （P 〈 0.01）. PLT counts in treatment group increased significantly after treatment, while MPV, PDW decreased significantly （P 〈 0.01）. ②PLT counts in observation group before observation were significantly lower than that of control group, while MPV, PDW were significantly higher than that in control group. The differences between the two groups were statistically significant （P 〈 0.0l）. PLT counts in observation group increased significantly after observation, while PDW decreased significantly （P 〈 0.05）. Conclusion Childhood acute ITP is a benign self-limiting disease with rapid recovery and better prognosis. Excessive examination and treatment should be avoided.