结肠癌发病风险的病例对照研究

The risk factors of colonic cancer:A case-control study

目的研究影响结肠癌发病的危险因素，为预防和控制结肠癌的发生提供理论基础。方法本次研究采用病例对照研究的方法，回顾性收集在我院住院的85例结肠癌患者作为病例组，并选取同期住院的非肿瘤患者作为对照组，收集相关资料，研究影响结肠癌发生的危险因素。结果单因素分析发现，文化程度低（OR=3．43，95％CI：1．81～6．50）、体育锻炼少（OR=2．14，95％CI：1．17～3．94）、食用新鲜蔬菜少（OR=3．67，95％CI：1．95—6．90）、恶性肿瘤家族史（OR=2．58，95％CI：1．03～6．50）、阑尾炎史（OR=4．61，95％CI：1．74～12．16）是结肠癌发病的危险因素；多元Logistic回归模型进行分析发现，文化程度低（OR=1．548，95％CI：1．397～6．492）、食用新鲜蔬菜少（OR=I．731，95％CI：1．306—5．439）、阑尾炎史（OR=I．489，95％CI：1．197～3．972）是结肠癌发病的独立危险因素。结论低文化程度、食用新鲜蔬菜少、有阑尾炎史的人群是结肠癌高发的人群，针对这类重点人群需要加强预防和干预。

Objective To study the risk factors of colonic and provide the basis to prevent and control the disease. Methods The case-control study was used. Retrospectively collected the informantion of 85 cases of colon cancer patients in our hospital as case group and selected the corresponding period of non-hospitalized cancer patients as a control group. Results Univariate analysis showed that low educational level （OR=3.43,95%CI： 1.81-6.50）,physical exercise less （0R=2.14,95%CI： 1.17-3.94）, consumption of fresh vegetables and less（OR--3.67,95%Cl： 1.95-6.90）, family history of cancer （OR=2.58,95%CI： 1.03-6.50）, history of appendicitis （OR=4.61,95%CI： 1.74-12.16） is a risk factor for colon cancer; multiple Logistic regression analysis found that low educational level （OR=1.548,95% CI： 1.397-6.492）, consumption of fresh vegetables and less （OR=1.731,95%CI- 1.306-5.439）, history of appendicitis （OR=1.489,95%CI： 1.197-3.972） was an independent risk factor for colon cancer. Conclusion The populations with low education level, consumption less fresh vegetables and the history of appendicitis are the high risk people, and it is necessary to strengthen the prevention and intervention.